The Role of Cannabinol (CBN) in Protecting Brain Cells: A New Frontier

According to the WHO, one out of six people will be over 60 by 2030, and the senior population will reach around 1.4 billion. The rapid pace of population aging highlights the importance of wellness and fitness goals so older adults can continue contributing to the economy and place less burden on healthcare resources.

One of the major challenges aging individuals face is mental disorders and impaired cognition, which significantly affects the quality of life. Therefore, various studies have been conducted to evaluate their root causes and find therapeutic solutions for protecting brain cells, and CBN is one of them.

CBN, or cannabinol, has been found effective in preventing age-related mental issues such as dementia and Alzheimer’s disease. With its potential role in protecting brain cells, it can be one of the most promising therapeutic targets for seniors, helping them continue to exploit their full abilities and contribute to society. Explore the potential role of CBN in human health and the benefits it may offer for the older generation.

CBN: Promising Neuroprotective Effects

Mitochondria are subcellular organelles responsible for energy production, hormone synthesis, and cell signaling. These organelles have been studied extensively, as mitochondrial dysfunction is considered a major factor behind psychiatric and age-related mental issues.

Mitochondria are highly vulnerable to oxidative stress and aging-related damage. Mitochondrial transcription factor A (TFAM) and translocase of the outer mitochondrial membrane 20 (TOM20) are two key proteins required for healthy brain functioning. 

TFAM supports the replication of mitochondrial DNA (mtDNA), providing enough chemical energy to brain cells. This energy is essential for performing various biochemical reactions that determine cognitive functions such as learning and memory. With age, the levels of these proteins decrease, which ultimately affects the mitochondrial biogenesis process. 

CBN has been found effective in increasing the production of Superoxide Dismutase 2 (SOD2), a mitochondrial antioxidant enzyme that plays a crucial role in protecting brain cells against oxidative damage. As SOD2 levels naturally decline with age, the brain becomes more vulnerable to DNA and cellular damage. CBN treatment acts as a mitochondrial protective agent and helps improve antioxidant defense.

Potential Benefits of CBN Cannabinoid for Mental Wellness

Why are researchers advocating the positive effects of this novel cannabinoid for mental health? Let’s take a look at its potential benefits, backed by scientific evidence.

Stress Management

According to research, people are more prone to neuropsychiatric disorders if they suffer from chronic stress. Anxiety and stress adversely affect brain functioning if persistent over a long period. Patients are also at increased risk of developing dementia, as these conditions affect the hippocampus and prefrontal cortex (PFC), brain regions responsible for memory formation, decision-making, and other cognitive functions.

CBN may help patients with anxiety, depression, or stress due to its mild psychoactive effects. Research suggests that by reducing oxidative stress, CBN can be beneficial in protecting against various neurodegenerative disorders. It also promotes a calming effect on the nervous system, helping individuals respond to stressors in a controlled and balanced manner. 

However, more evidence is required to understand the direct link of CBN in addressing psychological issues and how it impacts memory regulation and mental stability.

Sleep Hygiene

Sleep quality and cognitive performance are closely linked. Research shows that good sleep hygiene contributes to memory consolidation. Those who suffer from insomnia or other sleep issues often experience impaired cognition, reduced decision-making power, and negative effects on mental health, such as depression and stress. 

Moreover, long-term sleep deprivation gives rise to irreversible hippocampal alterations, which are linked with multiple cognitive disorders. Continuous intake of 20 mg of CBN was found to be effective in improving sleep quality. Another study supports the role of CBN in reducing nighttime awakenings. With better sleep hygiene, it may help support smooth cognitive functioning, promoting overall mental health.

Limitations and Possible Side Effects

Oral administration of CBD treatment in small doses is often regarded as safe for adults. There are no reported cases of serious side effects, but long-term use and overdosing are still in question. More scientific studies are needed to elaborate its potential effects on the human body, particularly when taken for longer durations. 

Some minor side effects that users often complain about include:

• Increase or decrease in appetite

• Dizziness

• Tiredness

• Stomach issues

• Dry mouth

There is no clear evidence about its safety during pregnancy or breastfeeding, and one must consult a medical health provider before usage. Moreover, patients who are already on certain medications should use them with care or only after consultation, as cannabinoids can alter or reduce the efficacy of various medications.

CBN Legal Status and Federal Rules

According to the 2018 Farm Bill, CBN derived from hemp and containing no more than 0.3% THC is considered legal, and you can purchase and use such products within the United States. However, this cannabinoid is only mildly psychoactive and does not produce harmful effects like high-THC products.

It is not part of the federal controlled substance schedules, so its products, such as gummies, oils, and tinctures, are considered legal. However, if manufacturers use any cannabis source other than hemp for extraction, the product becomes illegal.

Likewise, regulations and legal status vary from state to state, but the majority of U.S. states classify it as legal, including Alabama, Colorado, Connecticut, Delaware, Illinois, Kentucky, Louisiana, Maine, New York, North Carolina, North Dakota, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, and others.

CBN Is Revolutionizing Wellness Trends

Currently, with increased focus on CBD and other cannabinoid compounds, CBN is still relatively new for people to adopt as part of their general health practices or for supporting their mental well-being. However, federal laws that support hemp-based CBD as legal are promoting its sale, but compared to CBD, its market share is still quite low.

With more scientific evidence, public awareness, and supportive regulations, its use and market expansion are expected to grow. This will open new doors for manufacturers in the near future and help seniors live a healthier lifestyle by protecting their brain cells and overall well-being with this therapeutic cannabinoid.